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Updated: Jul 9, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Current status of the surgical treatment of atrial fibrillation
Alexander S Geha1, Khaled Abdelhady
1Division of Cardiothoracic Surgery, The University of Illinois Medical Center at Chicago, 840 S. Wood Street, CSB 417 (MC 958), Chicago, Illinois 60612, United States. Ageha@uic.edu
Insights
Atrial fibrillation (AF) treatment options are limited, with pharmacological therapy being only 50% effective. This study reviews ablative procedures, including catheter-based methods, for treating AF and associated cardiac conditions.
Area of Science:
- Cardiology
- Cardiac Surgery
- Electrophysiology
Background:
- Atrial fibrillation (AF) impacts millions globally, often co-occurring with coronary artery disease, rheumatic heart disease, hypertension, and congestive heart failure.
- Current pharmacological treatments for AF demonstrate limited efficacy, often below 50%.
- AF commonly originates from macro-re-entrant circuits within the left atrium, frequently linked to mitral valve disease.
Purpose of the Study:
- To comprehensively review current ablative surgical and catheter-based procedures for atrial fibrillation (AF).
- To detail the indications, advantages, and disadvantages of various AF ablation techniques.
- To present outcomes from a cohort of 50 patients with AF and coexisting cardiac conditions treated with alternative ablation methods.
Main Methods:
- Review of established and novel ablative techniques for atrial fibrillation (AF), including the Cox Maze procedure.
- Description of catheter ablation modalities: cryoablation, radiofrequency ablation (dry and irrigated), laser, and microwave ablation.
- Analysis of clinical outcomes in 50 patients undergoing alternative ablation strategies for AF with associated cardiac lesions.
Main Results:
- Pharmacological therapy for AF has a success rate of approximately 50%.
- Ablative procedures offer alternative therapeutic options beyond medication and cardioversion.
- The study presents specific outcomes for 50 patients treated with non-surgical ablation techniques for AF.
Conclusions:
- Ablative procedures, particularly catheter-based methods, represent crucial advancements in managing atrial fibrillation (AF).
- Alternative ablation techniques offer effective atrial scarring, providing viable options for patients with complex cardiac conditions.
- The presented patient experience highlights the potential of these alternative approaches in treating AF.
Abstract:
Atrial fibrillation (AF) affects several million patients worldwide and is associated with a number of heart conditions, particularly coronary artery disease, rheumatic heart disease, hypertension, and congestive heart failure. The treatment of AF and its complications is quite costly. Atrial fibrillation usually results from multiple macro-re-entrant circuits in the left atrium. Very frequently, particularly in association with mitral valve disease, these circuits arise from the area of the junction of the pulmonary venous endothelium and the left atrial endocardium. Pharmacological therapy is at best 50% effective. Therapeutic options for AF include antiarrhythmic drugs, cardioversion, atrioventricular (A-V) node block, pacemaker insertion, and ablative surgery. In 1987, Cox developed an effective surgical procedure to achieve ablation. Current ablative procedures include the classic cut-and-sew Maze operation or a modification of it, namely through catheter ablation, namely, cryoablation, radiofrequency ablation (dry or irrigated), and other forms of ablation (e.g., laser, microwave). These procedures will be described, along with the indications, advantages and disadvantages of each. Special emphasis on the alternative means to cutting and sewing to achieve appropriate effective atrial scars will be stressed, and our experience with these approaches in 50 patients with AF and associated cardiac lesions and their outcomes is presented.
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