Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Simplified apoptotic cascades.

Mehregan Movassagh1, Roger S-Y Foo

  • 1Division of Cardiovascular Medicine, Addenbrooke's Hospital, University of Cambridge, ACCI Building Level 6, Hills Road, Box 110, Cambridge CB2 2QQ, UK.

Heart Failure Reviews
|December 18, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thromboxane receptor activation in dendritic cells mitigates sepsis by suppressing S100a8/a9-mediated neutrophil recruitment.

Signal transduction and targeted therapy·2026
Same author

<i>CLIPPER</i> Regulates LPIN1-Mediated Mitochondrial Biogenesis and Heart Regeneration.

Circulation research·2026
Same author

Ferroptosis in heart failure: from molecular insights to therapeutic implications.

Cardiovascular research·2026
Same author

Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy.

Science (New York, N.Y.)·2026
Same author

Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery.

bioRxiv : the preprint server for biology·2025
Same author

Cardiovascular, Kidney, Liver, and Metabolic Interactions in Heart Failure: Breaking Down Silos.

Circulation research·2025
Same journal

Mavacamten in adolescent obstructive hypertrophic cardiomyopathy: SCOUTing a way forward.

Heart failure reviews·2026
Same journal

Overcoming barriers to early diagnosis and treatment of p.Val142Ile amyloid transthyretin (ATTR) cardiomyopathy.

Heart failure reviews·2026
Same journal

Beyond vasodilation: sotatercept and the remodeling hypothesis in hfpef-associated pulmonary hypertension.

Heart failure reviews·2026
Same journal

Beyond the right ventricle: left heart involvement in pulmonary arterial hypertension.

Heart failure reviews·2026
Same journal

Left ventricular non-compaction in heart failure: contemporary perspective on diagnostic challenges and treatment opportunities.

Heart failure reviews·2026
Same journal

Correction to: Left atrial shunting devices: why, what, how, and… when?

Heart failure reviews·2026
See all related articles

Apoptosis, a regulated cell death process, is crucial for development and homeostasis. Understanding its pathways is key to targeting cardiomyocyte apoptosis for heart failure therapy.

Area of Science:

  • Cellular biology
  • Biochemistry
  • Physiology

Background:

  • Apoptosis is a regulated cell death mechanism vital for development and homeostasis.
  • Two primary pathways, extrinsic and intrinsic, involve specific cellular components and protein families like caspases and Bcl-2 proteins.
  • Cardiomyocyte apoptosis is implicated in heart failure, directly causing dilated cardiomyopathy.

Purpose of the Study:

  • To elucidate the intricacies of apoptotic death pathways.
  • To determine the relevance of these pathways to cardiomyopathy.
  • To establish cardiomyocyte apoptosis as a potential pharmacological target for heart failure.

Main Methods:

  • Review of established knowledge on extrinsic and intrinsic apoptotic pathways.
  • Analysis of biochemical and morphological changes during apoptosis.

Related Experiment Videos

  • Examination of protein-protein interactions within apoptotic cascades, including death domain motifs.

    • Main Results:

    • Apoptosis involves distinct biochemical and morphological changes.
    • Both extrinsic and intrinsic pathways can be activated by apoptotic stimuli.
    • Cardiomyocyte apoptosis is a direct cause of dilated cardiomyopathy.

    Conclusions:

    • Understanding apoptotic pathways is essential for developing heart failure therapies.
    • Targeting cardiomyocyte apoptosis offers a potential therapeutic strategy for heart failure.
    • Further research into apoptotic mechanisms is crucial for clinical applications.