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Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
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Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction

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Radiation therapy in acromegaly.

Helen A Shih1, Jay S Loeffler

  • 1Department of Radiation Oncology, Massachusetts General Hospital, 100 Blossom St, Cox 3, Boston, MA 02114, USA. hshih@partners.org

Reviews in Endocrine & Metabolic Disorders
|December 18, 2007
PubMed
Summary

Radiation therapy can control growth hormone-secreting pituitary adenomas in acromegaly patients resistant to other treatments. It offers durable tumor control and biochemical remission, with techniques varying by adenoma characteristics.

Area of Science:

  • Endocrinology
  • Radiation Oncology
  • Neurosurgery

Background:

  • Growth hormone-secreting pituitary adenomas cause acromegaly.
  • Primary treatments include surgery and medical therapy.
  • Radiation therapy is typically reserved for refractory cases.

Purpose of the Study:

  • To review the role of radiation therapy in managing growth hormone-secreting pituitary adenomas.
  • To discuss radiation delivery techniques and their rationale.
  • To outline potential adverse effects of radiation treatment.

Main Methods:

  • Review of radiation therapy modalities for pituitary adenomas.
  • Discussion of stereotactic radiosurgery (single-session) and fractionated radiotherapy (multi-session).
  • Consideration of adenoma size and extrasellar extension in treatment planning.

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Main Results:

  • Radiation therapy provides durable tumor control in refractory acromegaly.
  • Biochemical remission is achievable with radiation treatment.
  • Technique and dose are tailored to individual patient and tumor factors.

Conclusions:

  • Radiation therapy is a valuable option for acromegaly patients with refractory pituitary adenomas.
  • Fractionated radiotherapy and stereotactic radiosurgery are key modalities.
  • Careful consideration of technique and potential side effects is essential.