Two new antibacterial sesquiterpenoids from Centipeda minima

Area of Science:

• Natural Product Chemistry
• Medicinal Chemistry
• Microbiology

Background:

• Centipeda minima is a plant known for its traditional medicinal uses.
• Sesquiterpene lactones are a class of natural products with diverse biological activities.

Purpose of the Study:

• To isolate and characterize new sesquiterpene lactones from Centipeda minima.
• To evaluate the antimicrobial potential of isolated compounds against various pathogens.

Main Methods:

• Isolation of compounds using chromatographic techniques.
• Structure elucidation via spectroscopic (NMR, MS) and mass-spectrometric analyses.
• Determination of antimicrobial activity using Minimum Inhibitory Concentration (MIC) assays.

Main Results:

• Two novel guaiane-type sesquiterpene lactones (compounds 1 and 2) were identified.
• Three known guaianolides/pseudoguaianolides were also isolated.
• All five compounds exhibited activity against eight microbial pathogens, with MIC values ranging from 6.25 to 100 µg/mL.

Conclusions:

• Centipeda minima is a source of bioactive guaiane sesquiterpene lactones.
• The isolated compounds show promising antimicrobial properties, warranting further investigation for therapeutic applications.