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Updated: Jul 9, 2026

Synthesis of Single-Crystalline Core-Shell Metal-Organic Frameworks
Published on: February 10, 2023
Synthetic studies on altemicidin: stereocontrolled construction of the core framework
Toshiyuki Kan1, Yuichiro Kawamoto, Tomohiro Asakawa
1School of Pharmaceutical Sciences, University of Shizuoka and COE Program in the 21st century, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. kant@u-shizuoka-ken.ac.jp
Abstract:
The stereoselective synthesis of the key intermediate for altemicidin has been accomplished. The synthesis commenced with a bicyclo[3.3.0] framework, which was readily obtained via an intramolecular C-H insertion reaction. A Curtius rearrangement was employed as a key step to stereoselectively construct the beta-hydroxyl alpha-disubstituted-alpha-amino acid structure. Synthesis of vinylogous urea was achieved using hydrolysis of nitrile intermediate.
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