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High altitude and retinal detachment.

Daniel S Morris1, Philip S Severn, Jonathan Smith

  • 1Department of Ophthalmology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK. danielsmorris@hotmail.com

High Altitude Medicine & Biology
|December 18, 2007
PubMed
Summary
This summary is machine-generated.

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A man developed bilateral retinal detachments after high-altitude trekking and taking acetazolamide for acute mountain sickness (AMS). This case suggests a potential link between high altitude, AMS prophylaxis, and retinal detachment.

Area of Science:

  • Ophthalmology
  • Altitude Medicine

Background:

  • Acetazolamide is commonly used for acute mountain sickness (AMS) prophylaxis.
  • Retinal detachment is a serious ocular condition.
  • High-altitude exposure presents unique physiological challenges.

Observation:

  • A 38-year-old male presented with bilateral retinal detachments after trekking in Tibet.
  • The patient had taken acetazolamide for AMS prophylaxis during his trek.
  • This is the first reported instance of retinal detachment following high-altitude exposure.

Findings:

  • The patient experienced retinal detachments after high-altitude travel and acetazolamide use.
  • Acetazolamide has no prior association with retinal detachment in AMS prophylaxis or ophthalmic use.
  • The patient recovered well after surgical intervention for retinal detachment.

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Implications:

  • The case suggests a potential, though unproven, association between high altitude, acetazolamide use, and retinal detachment.
  • Hypobaric hypoxia and vitreous dehydration are hypothesized mechanisms.
  • Further research is warranted to explore potential causal links and risk factors.