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Potential benefit of Sunitinib in recurrent and refractory ovarian clear cell adenocarcinoma

J A Rauh-Hain1, R T Penson

  • 1Division of Clinical Gynecologic Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
|December 18, 2007
PubMed

Insights

Ovarian clear cell adenocarcinoma (OCCA) may respond to Sunitinib, a targeted therapy. Further clinical trials are needed to confirm efficacy in recurrent and refractory OCCA cases.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Ovarian clear cell adenocarcinoma (OCCA) is a distinct epithelial ovarian cancer subtype.
  • OCCA shares molecular similarities with renal cell carcinoma (RCC).
  • Sunitinib, a tyrosine kinase inhibitor, shows efficacy in RCC treatment.

Observation:

  • A patient with recurrent, refractory stage IA OCCA after 9 years in remission was treated.
  • Sunitinib was administered as a fifth-line chemotherapy.
  • The treatment led to cystic degeneration of liver metastasis and a decrease in CA125 levels.

Findings:

  • Sunitinib demonstrated a potential positive response in a patient with extensively pretreated, recurrent OCCA.
  • Observed cystic degeneration in liver metastasis suggests drug activity.
  • A transient decrease in CA125 tumor marker was noted.

Implications:

  • Sunitinib presents a potential therapeutic option for refractory OCCA.
  • The findings support further investigation of Sunitinib in OCCA.
  • Clinical trials are essential to validate Sunitinib's efficacy and determine its role in OCCA treatment, especially in heavily pretreated patients.

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