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Intracranial haemorrhage in haemophilia A and B

Rolf C R Ljung1

  • 1Department of Paediatrics, Lund University, University Hospital, Malmö, Sweden. rolf.ljung@med.lu.se

British Journal of Haematology
|December 18, 2007
PubMed

Insights

Intracranial hemorrhage (ICH) is significantly more common in boys with hemophilia, especially during the neonatal period. This risk persists throughout life, influenced by factors like inhibitors and age-related conditions.

Area of Science:

  • Medical Science
  • Hematology
  • Pediatrics

Background:

  • Intracranial hemorrhage (ICH) is a serious complication in hemophilia patients.
  • Neonatal ICH affects 3.5-4.0% of hemophilia boys, significantly higher than the general population.

Purpose of the Study:

  • To review the incidence and risk factors of intracranial hemorrhage in hemophilia patients.
  • To inform treatment strategies by understanding ICH prevalence across different patient groups and ages.

Main Methods:

  • Literature review of studies on intracranial hemorrhage in hemophilia.
  • Analysis of ICH incidence based on age, treatment regimens, and disease severity.

Main Results:

  • ICH is more frequent in neonates and patients treated on demand; risk is higher with inhibitors.
  • Spontaneous hemorrhages are more common than trauma-induced ones.
  • ICH occurs in adults, with age-related factors like hypertension becoming significant; milder hemophilia forms also show risk.

Conclusions:

  • Intracranial hemorrhage is a considerable risk for hemophilia patients throughout their lives.
  • Treatment strategies must account for the varying risks of ICH across different patient demographics and clinical presentations.

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