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Related Concept Videos

Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

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Related Experiment Video

Updated: Jul 9, 2026

Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis
06:45

Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

[Relationship between soluble intercellular adhesion molecule-1 and severe pneumonia].

Chun-Yi Liu1, Ping Jin, Yan-Xia Yang

  • 1Bao'an Maternal and Child Health Care Hospital, Shenzhen, Guangdong, China. chunyi8@hotmail.com

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|December 18, 2007
PubMed
Summary

Soluble intercellular adhesion molecule-1 (sICAM-1) levels are significantly elevated in children with severe pneumonia, indicating its role in the inflammatory process. sICAM-1 can serve as a diagnostic and severity marker for pediatric severe pneumonia.

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Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling
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Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

Published on: April 7, 2015

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Last Updated: Jul 9, 2026

Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis
06:45

Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling
08:25

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

Published on: April 7, 2015

Area of Science:

  • Pediatric Immunology
  • Respiratory Medicine
  • Inflammation Biomarkers

Context:

  • Severe pneumonia is a significant health concern in children.
  • The role of soluble intercellular adhesion molecule-1 (sICAM-1) in pediatric severe pneumonia pathogenesis remains incompletely understood.
  • Immune and inflammatory responses are central to pneumonia development.

Purpose:

  • To investigate the expression levels of sICAM-1 in children diagnosed with severe pneumonia.
  • To explore the relationship between sICAM-1 levels and the severity of pneumonia in pediatric patients.
  • To assess sICAM-1 as a potential biomarker for diagnosis and severity evaluation.

Summary:

  • Serum sICAM-1 levels were significantly higher in children with severe pneumonia compared to those with mild pneumonia and healthy controls.
  • sICAM-1 levels decreased significantly during the recovery stage in severe pneumonia cases.
  • No significant differences in sICAM-1 levels were observed among different pathogen-induced severe pneumonia subgroups or based on treatment success.

Impact:

  • Findings suggest sICAM-1 is involved in the inflammatory cascade of severe pneumonia in children.
  • sICAM-1 demonstrates potential as a valuable biomarker for diagnosing and assessing the severity of pediatric severe pneumonia.
  • This research contributes to understanding the immunological underpinnings of severe pneumonia.