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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

[Influence of cardiopathy etiology on responses to cardiac resynchronization therapy]

Bàrbara Vidal1, Marta Sitges, Victoria Delgado

  • 1Institut Clínic del Tòrax, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, España.

Revista Espanola De Cardiologia
|December 18, 2007
PubMed

Insights

Cardiac resynchronization therapy (CRT) improves heart function and reduces ventricular size in patients with systolic dysfunction and left bundle branch block (LBBB). The benefits of CRT for reverse left ventricular remodeling are consistent regardless of the underlying cause of heart disease.

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Medical Devices

Background:

  • Cardiac resynchronization therapy (CRT) is a treatment for heart failure.
  • The impact of cardiopathy etiology on CRT response is not well understood.
  • Reverse left ventricular remodeling is a key indicator of treatment success.

Purpose of the Study:

  • To investigate how the cause of heart disease (cardiopathy etiology) affects the success of CRT in improving left ventricular remodeling.
  • To assess the influence of cardiopathy etiology on CRT's impact on reverse left ventricular remodeling.

Main Methods:

  • 106 patients with left ventricular systolic dysfunction and left bundle branch block (LBBB) receiving CRT were studied.
  • Clinical and echocardiographic data were collected at baseline and at 6 and 12 months post-implantation.
  • Measurements included left ventricular dimensions, volume, systolic function (LVEF), and mitral regurgitation.

Main Results:

  • CRT significantly reduced left ventricular volume and diameter, and improved left ventricular ejection fraction (LVEF) and mitral regurgitation.
  • These improvements occurred irrespective of whether the heart disease was ischemic or idiopathic in origin.
  • No significant differences in clinical response rates were observed between patients with ischemic versus non-ischemic dilated cardiomyopathy.

Conclusions:

  • Cardiac resynchronization therapy (CRT) leads to significant reverse left ventricular remodeling and clinical improvement in patients with systolic dysfunction and left bundle branch block (LBBB).
  • The etiology of the underlying cardiopathy does not appear to influence the effectiveness of CRT in achieving reverse ventricular remodeling at 12-month follow-up.
Abstract

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