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Updated: Jul 9, 2026

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
Published on: April 18, 2016
Division of labor, plasticity, and crosstalk between dendritic cell subsets
Bali Pulendran1, Hua Tang, Timothy L Denning
1Emory Vaccine Center, 954 Gatewood Road, Atlanta, GA 30329, USA. bpulend@rmy.emory.edu
Abstract:
For years, dendritic cell (DC) biologists have oscillated between two seemingly antagonistic ideas: functional specialization (division of labor) of DC subsets and plasticity (multitasking). More recently, a third hypothesis is gathering support: crosstalk between functionally distinct DC subsets. This reveals a previously unappreciated hierarchy of organization within the DC system, and provides a conceptual framework to understand how cooperation between functionally distinct, yet plastic, DC subsets can shape adaptive immunity and immunological memory. Here we review the recent advances in this area.
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