Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Genetic Lingo01:11

Genetic Lingo

Overview
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...
Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
Test for Homogeneity01:23

Test for Homogeneity

The goodness–of–fit test can be used to decide whether a population fits a given distribution, but it will not suffice to decide whether two populations follow the same unknown distribution. A different test, called the test for homogeneity, can be used to conclude whether two populations have the same distribution. To calculate the test statistic for a test for homogeneity, follow the same procedure as with the test of independence. The hypotheses for the test for homogeneity can be stated as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The combination of atezolizumab and BCG in high-risk non-muscle invasive bladder cancer: results of the phase Ib/II BladderGATE clinical trial.

The oncologist·2026
Same author

CD44v6 is associated with tumor aggressiveness and chemoresistance in bladder cancer.

Scientific reports·2026
Same author

Individual- and population-level associations of mental disorders with intentional self-harm.

European psychiatry : the journal of the Association of European Psychiatrists·2026
Same author

Cell-of-origin and genetic drivers define advanced bladder cancer subtypes and potential therapeutic response in mouse models.

Journal of experimental & clinical cancer research : CR·2026
Same author

Diagnostic Accuracy of "System for the Assessment of Children and Adolescents" (SENA) for Emotional Disorders in Youth: Insights from the EmoChild Study in Spain.

Psychiatry research·2026
Same author

Corrigendum to "Subtypes of suicidal ideation among university students - An ecological momentary assessment study" [J. Affect. Disord. 391 (2025) 119865].

Journal of affective disorders·2026

Related Experiment Video

Updated: Jul 9, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

HLA class I polymorphism in the Cuban population.

Annia Ferrer1, Marcelo Nazábal, Osmel Companioni

  • 1Center of Genetic Engineering and Biotechnology, Havana, Cuba. annia.ferrer@cigb.edu.cu

Human Immunology
|December 18, 2007
PubMed
Summary

The genetic diversity of the Cuban population was analyzed using Human Leukocyte Antigen (HLA) class I genes. This study reveals significant interethnic admixture, highlighting contributions from African, European, Amerindian, and Asian ancestries.

More Related Videos

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

Related Experiment Videos

Last Updated: Jul 9, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

Area of Science:

  • Population Genetics
  • Immunogenetics
  • Human Evolution

Background:

  • Human Leukocyte Antigen (HLA) system exhibits extreme polymorphism, making it crucial for population genetic studies.
  • Understanding HLA diversity aids in tracing population history and disease associations.

Purpose of the Study:

  • To estimate the genetic polymorphism of the Cuban population at HLA-A, -B, and -Cw loci.
  • To determine HLA class I allele and haplotype diversity in Cuban whites and mulattos.

Main Methods:

  • DNA typing was employed to analyze HLA class I loci in 390 unrelated Cuban individuals.
  • Allele and haplotype frequencies were calculated and compared with global populations using genetic distances, neighbor-joining dendrograms, and correspondence analyses.

Main Results:

  • Identified 19, 27, and 14 allele families for HLA-A, -B, and -Cw in whites, and 20, 18, and 14 in mulattos, respectively.
  • Detected common alleles and haplotypes with sub-Saharan African and European populations.
  • Observed lower frequencies of Amerindian and Asian alleles, indicating interethnic admixture.

Conclusions:

  • The Cuban population exhibits high genetic diversity and significant interethnic admixture.
  • Findings provide valuable data for future studies on Cuban population evolution and HLA-associated diseases.