Recurrent carotid stenosis after CEA and CAS: diagnosis and management

Carotid endarterectomy (CEA) is the preferred method for cerebral revascularization in patients with symptomatic and asymptomatic high-grade extracranial carotid artery stenosis. Carotid artery stenting (CAS) has recently emerged as a less invasive alternative to endarterectomy. Carotid stenting has been demonstrated to be technically feasible and safe in high-risk patients. It has been approved as an acceptable method for revascularization in circumstances where CEA yields suboptimal results. While the final role of CAS in carotid revascularization will be determined on the basis of ongoing randomized trials, it is clear that stenting will continue to be performed in subgroups of patients with carotid stenosis. Therefore, it is anticipated that there will be a corresponding increase in the number of in-stent restenosis cases. Considerable controversy exists regarding the clinical significance, natural history, threshold for management, and appropriate intervention of recurrent carotid stenosis after endarterectomy and after stenting. This review analyzes current information on this important clinical problem and presents evidence-based recommendations for the diagnosis and management of recurrent carotid stenosis.