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Relationships between multiple self-reported nonadherence measures and pharmacy records
Nathaniel M Rickles1, Bonnie L Svarstad
1Department of Pharmacy Practice and Administration, School of Pharmacy, Northeastern University, 360 Huntington Avenue, 206 Mugar Life Sciences Building, Boston, MA 02115, USA. n.rickles@neu.edu
Research in Social & Administrative Pharmacy : RSAP
|December 18, 2007
Summary
Simple oral and written self-reports effectively measure medication nonadherence. These methods correlate with pharmacy records and predict future nonadherence, aiding timely interventions.
Area of Science:
- Pharmacology and Pharmaceutics
- Health Services Research
- Patient Adherence Studies
Background:
- Medication nonadherence significantly impedes optimal therapeutic outcomes.
- Accurate measurement of patient adherence presents considerable methodological challenges.
- Healthcare providers require simple tools to assess adherence that align with established methods.
Purpose of the Study:
- To evaluate the concordance between monthly oral and 3-month written self-reported nonadherence estimates.
- To compare self-reported nonadherence measures with pharmacy refill records.
- To determine the predictive value of self-reported nonadherence for current and future medication adherence.
Main Methods:
- Study involved 63 patients with new antidepressant prescriptions across 8 Wisconsin community pharmacies.
- Oral and written self-report adherence measures were adapted from the Brief Medication Questionnaire.
- Pharmacy records were obtained from participating pharmacies and the managed care organization.
Main Results:
- Oral self-reported nonadherence showed significant correlation with written reports at 12 weeks (P<0.001).
- Oral self-reports at 8 and 12 weeks predicted adherence via pharmacy records from months 1-6 (P<0.05).
- Written self-report at 12 weeks significantly correlated with and predicted nonadherence over 6 months (P<0.001).
Conclusions:
- Oral and written self-report adherence measures demonstrate moderate to strong concordance with pharmacy records.
- Both self-report methods effectively predict medication nonadherence over a 6-month period.
- Brief self-report questions are valuable for identifying nonadherence and prompting interventions.
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