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Related Concept Videos

Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Measurement of Bioavailability: Pharmacodynamic Methods01:20

Measurement of Bioavailability: Pharmacodynamic Methods

Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.
Purpose of Health Records I01:11

Purpose of Health Records I

The vital purpose of health records is to provide a complete and accurate account of a patient's medical history, including communication, diagnostic and therapeutic orders, care planning, research, and quality review.
Here's a breakdown of how health records serve these purposes:
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis00:59

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This relationship...

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Related Experiment Videos

Relationships between multiple self-reported nonadherence measures and pharmacy records.

Nathaniel M Rickles1, Bonnie L Svarstad

  • 1Department of Pharmacy Practice and Administration, School of Pharmacy, Northeastern University, 360 Huntington Avenue, 206 Mugar Life Sciences Building, Boston, MA 02115, USA. n.rickles@neu.edu

Research in Social & Administrative Pharmacy : RSAP
|December 18, 2007
PubMed
Summary

Simple oral and written self-reports effectively measure medication nonadherence. These methods correlate with pharmacy records and predict future nonadherence, aiding timely interventions.

Related Experiment Videos

Area of Science:

  • Pharmacology and Pharmaceutics
  • Health Services Research
  • Patient Adherence Studies

Background:

  • Medication nonadherence significantly impedes optimal therapeutic outcomes.
  • Accurate measurement of patient adherence presents considerable methodological challenges.
  • Healthcare providers require simple tools to assess adherence that align with established methods.

Purpose of the Study:

  • To evaluate the concordance between monthly oral and 3-month written self-reported nonadherence estimates.
  • To compare self-reported nonadherence measures with pharmacy refill records.
  • To determine the predictive value of self-reported nonadherence for current and future medication adherence.

Main Methods:

  • Study involved 63 patients with new antidepressant prescriptions across 8 Wisconsin community pharmacies.
  • Oral and written self-report adherence measures were adapted from the Brief Medication Questionnaire.
  • Pharmacy records were obtained from participating pharmacies and the managed care organization.

Main Results:

  • Oral self-reported nonadherence showed significant correlation with written reports at 12 weeks (P<0.001).
  • Oral self-reports at 8 and 12 weeks predicted adherence via pharmacy records from months 1-6 (P<0.05).
  • Written self-report at 12 weeks significantly correlated with and predicted nonadherence over 6 months (P<0.001).

Conclusions:

  • Oral and written self-report adherence measures demonstrate moderate to strong concordance with pharmacy records.
  • Both self-report methods effectively predict medication nonadherence over a 6-month period.
  • Brief self-report questions are valuable for identifying nonadherence and prompting interventions.