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Updated: Jul 9, 2026
Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
Published on: August 15, 2022
[The outcome of the living donor]
1Service de néphrologie et d'immunologie clinique, CHU de Nantes, 44093 Nantes cedex, France. maryvonne.hourmant@chu-nantes.fr
Insights
Living kidney donation carries an extremely low risk of morbi-mortality for donors. Long-term outcomes are favorable, with renal function maintained and mortality lower than the general population, though blood pressure monitoring is crucial.
Area of Science:
- Nephrology
- Transplant Surgery
- Public Health
Context:
- Living kidney donation is a critical procedure for end-stage renal disease patients.
- Understanding donor risks and long-term outcomes is essential for ethical and safe donation practices.
Purpose:
- To comprehensively review the morbi-mortality risks associated with living kidney donation.
- To evaluate the long-term health status and renal function of kidney donors.
Summary:
- The peri-operative mortality risk for living kidney donors is extremely low (0.03%), with severe complications occurring in 0.3-1% of cases.
- Donors exhibit better long-term mortality than the general population, with renal function stabilizing around 75% of pre-donation levels.
- While renal risks like proteinuria are low, post-nephrectomy hypertension requires careful blood pressure monitoring in predisposed individuals.
Impact:
- Provides crucial data for informed consent and donor selection processes in living kidney donation.
- Highlights the safety and long-term benefits of kidney donation, potentially encouraging more individuals to consider donation.
- Emphasizes the importance of lifelong follow-up for kidney donors, particularly regarding cardiovascular health.
Abstract:
There is no zero risk of morbi-mortality for the donor in the procedure of living donation of a kidney but according to the literature, this risk is extremely low. Mortality in the per- et peri-operative period is estimated to be 0.03% and severe postoperative complications, requiring or not surgery, between 0.3 and 1%. The long-term mortality of these donors, selected for their good health, is better than that of the general population paired for age. Renal function after donation is around 75% the predonation and declines with age as and no more than in every person with two kidneys. Although significant proteinuria (>1gr/l) in 3% of the donors and cases of end stage renal disease have been reported, the renal risk remains low. Among the parameters of follow-up, a special consideration has to be made for blood pressure as it will significantly increase after nephrectomy with a possible risk of developing hypertension in predisposed persons.
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