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Gene targeting in embryonic stem cells scores a knockout in Stockholm

Tak Wah Mak1

  • 1Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada M5G 2C1. tmak@uhnres.utoronto.ca

Cell
|December 18, 2007
PubMed

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.