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Published on: October 31, 2012
TNF and sTNFR1/2 plasma levels in ALS patients
Cristina Cereda1, Chiara Baiocchi, Paolo Bongioanni
1Neurological Institute IRCCS "C. Mondino", Pavia, Italy. cristina.cereda@mondino.it
Abstract:
The involvement of the immune system has been hypothesized in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study a significantly higher level of TNF-alpha and its soluble receptors, TNF-R1 and TNF-R2, has been found in plasma of patients affected by the sporadic form of ALS compared to normal subjects. The genetic analysis of the polymorphisms of TNF-alpha, TNF-R1 and TNF-R2 showed no statistically significant differences in alleles and genotype frequencies between patients and controls. These data suggest a participation of the immune system in response to as far unknown intracellular signals.
