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Altered emotionality, spatial memory and cholinergic function in caveolin-1 knock-out mice.

Laura Gioiosa1, Carla Raggi, Laura Ricceri

  • 1Department Cell Biology and Neuroscience, Sect of Behavioural Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, Roma, Italy.

Behavioural Brain Research
|December 18, 2007
PubMed
Summary

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Mice lacking caveolin 1 (cav-1) exhibit anxiety and spatial memory deficits. Loss of cav-1 also alters central nervous system cholinergic function and affects behavioral sex differences.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Behavioral Genetics

Background:

  • Caveolin 1 (cav-1) is a key structural protein in caveolar vesicles, crucial for cellular signaling and cholesterol transport.
  • Cav-1 is highly expressed in brain neurons and glia, suggesting a vital role in central nervous system function.
  • Recent studies indicate neurological phenotypes associated with cav-1 loss in mice.

Purpose of the Study:

  • To investigate the emotional and cognitive behavioral domains in mice deficient in cav-1 (CavKO mice).
  • To explore the impact of cav-1 deficiency on spatial/working memory and locomotor activity.
  • To assess the role of cav-1 in central cholinergic system function and behavioral responses to cholinergic antagonists.

Main Methods:

  • Behavioral testing of CavKO mice and wild-type (wt) littermates.

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  • Assessment of anxiety-like behaviors, self-directed grooming, and locomotor activity.
  • Spatial/working memory tasks, including object displacement recognition.
  • Evaluation of behavioral responses to the cholinergic muscarinic antagonist, scopolamine.

    • Main Results:

    • CavKO mice displayed increased anxiety and self-directed grooming compared to wt mice.
    • A significant spatial memory impairment was observed in CavKO mice, evidenced by failure in object displacement recognition.
    • CavKO mice exhibited higher locomotor activity, suggesting reduced CNS cholinergic inhibitory function.
    • Behavioral responses to scopolamine were diminished in CavKO mice.
    • Sex differences in behavior were attenuated or reversed in CavKO mice.

    Conclusions:

    • Loss of caveolin 1 results in a distinct behavioral phenotype in mice, characterized by anxiety and cognitive deficits.
    • Cav-1 deficiency selectively alters central cholinergic function.
    • The study highlights the critical role of cav-1 in regulating emotional, cognitive, and motor behaviors, as well as sex-specific behavioral patterns.