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Preimplantation aneuploidy screening: a research tool for now

Paul Devroey1, Bart C J M Fauser

  • 1Centre of Reproductive Medicine, Brussels Free University, 1090 Brussels, Belgium. paul.devroey@az.vub.ac.be

Lancet (London, England)
|December 18, 2007
PubMed
Summary

No abstract available in PubMed .

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Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...

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