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Dolasetron-induced torsades de pointes.

Sarah Turner¹, Letha Mathews, Pratik Pandharipande

¹Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA. thesooner@aol.com

Journal of Clinical Anesthesia

|December 18, 2007

Summary

A patient with Graves

Area of Science:

Neurosurgery
Cardiology
Pharmacology

Background:

A 52-year-old woman with hypertension and Graves' disease underwent meningioma removal.
The patient received prophylactic dolasetron before emergence.

Observation:

Intraoperative hypotension necessitated vasopressin infusion.
Post-extubation, the patient remained neurologically intact.

Findings:

During transport to the ICU, the patient developed torsades de pointes.
Cardiopulmonary resuscitation was required, achieving return of spontaneous circulation.

Implications:

This case highlights a potential association between dolasetron and QT prolongation in patients with pre-existing cardiovascular risk factors.

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Careful cardiac monitoring is crucial in patients with meningioma, hypertension, and Graves' disease, especially after dolasetron administration.