Lycopus europaeus (Gypsywort): effects on the thyroidal parameters and symptoms associated with thyroid function

Area of Science:

• Endocrinology
• Herbal Medicine Research

Background:

• Hyperthyroidism is a condition characterized by overactive thyroid function.
• Subtle forms of hyperthyroidism often present with non-specific symptoms.
• Lycopus europaeus (Bugleweed) has been traditionally used for various ailments.

Purpose of the Study:

• To investigate the effects of Lycopus europaeus herba on thyroid function.
• To assess the impact on hyperthyroidism-associated symptoms.
• To measure T3/T4 excretion in 24-hour urine as a primary objective parameter.

Main Methods:

• Prospective, two-armed, open study design.
• Inclusion of patients with basal TSH < 1.0 mU/l and hyperthyroidism symptoms.
• Measurement of urinary T3/T4 excretion, other hormones, general condition, and symptoms over a 3-month follow-up.

Main Results:

• Urinary T4 excretion was significantly increased in patients treated with Lycopus europaeus (p=0.032).
• Renal mechanisms are hypothesized to be responsible for increased T4 excretion.
• Hyperthyroidism-specific symptoms, such as morning heart rate, were diminished.
• The Lycopus europaeus preparation demonstrated good tolerance.

Conclusions:

• Lycopus europaeus may positively influence mild hyperthyroidism.
• The herb appears to reduce specific thyroid-related symptoms.
• Further research into the renal mechanisms of T4 excretion is warranted.