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Related Experiment Video

Updated: Jul 9, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Targeting the development and effector functions of TH17 cells.

Nico Ghilardi¹, Wenjun Ouyang

¹Department of Molecular Biology, Genentech Inc., 1-DNA Way, South San Francisco, CA 94080, USA. ghilardi@gene.com

Seminars in Immunology

|December 18, 2007

Summary

T helper 17 (TH17) cells are a distinct CD4+ T cell subset that secrete IL-17, IL-17F, and IL-22. These cells are critical in inflammation and autoimmune diseases, presenting potential therapeutic targets.

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Area of Science:

Immunology
Cell Biology

Background:

T helper (TH) cells differentiate into various phenotypes, including TH1, TH2, and regulatory T cells, each with distinct effector molecules.
TH17 cells represent a novel CD4+ subset characterized by the production of signature cytokines: IL-17, IL-17F, and IL-22.
TH17 cells are implicated in sustaining inflammatory responses and are associated with autoimmune diseases, highlighting their significance as therapeutic targets.

Purpose of the Study:

This review focuses on the regulatory mechanisms governing the differentiation of naive T cells into TH17 cells.
The review also examines TH17 effector cytokines as potential targets for therapeutic intervention.

Main Methods:

This is a review article, synthesizing existing research on TH17 cell differentiation and function.
Literature search and analysis of studies investigating T cell subsets, cytokine production, and autoimmune disease pathogenesis.

Main Results:

TH17 cells are crucial for host defense against certain pathogens but also contribute to autoimmune pathology.
Understanding TH17 cell differentiation pathways and cytokine functions is key to developing targeted therapies.
The effector cytokines IL-17, IL-17F, and IL-22 secreted by TH17 cells are central to their pro-inflammatory role.

Conclusions:

TH17 cells are a critical player in immune responses and autoimmune diseases.
Targeting TH17 cell differentiation or their effector cytokines offers promising therapeutic strategies for inflammatory and autoimmune conditions.