Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Renal Failure: Dose Adjustments

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

Dose Size and Dosing Frequency: Determination Methods

Dose Size and Dosing Frequency: Determination Methods

Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...

Serum Laboratory Studies, Stool Test, Breath Test

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...

Dosage Regimens: Partial Pharmacokinetic Parameters

Dosage Regimens: Partial Pharmacokinetic Parameters

It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...

Drug Concentrations: Measurements

Drug Concentrations: Measurements

Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma —...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Plutonium Systemic Biokinetic Model for Rats.

Radiation research·2022

Same author

Doses from external irradiation and ingestion of <sup>134</sup>Cs, <sup>137</sup>Cs and <sup>90</sup>Sr of the population of Belarus accumulated over 35 years after the Chernobyl accident.

Radiation and environmental biophysics·2022

Same author

Dose Coefficients for Internal Dose Assessments for Exposure to Radioactive Fallout.

Health physics·2021

Same author

Dose and Dose-Rate Effects in a Mouse Model of Internal Exposure to 137Cs. Part 1: Global Transcriptomic Responses in Blood.

Radiation research·2020

Same author

Estimated Radiation Doses Received by New Mexico Residents from the 1945 Trinity Nuclear Test.

Health physics·2020

Same author

Association of Radioactive Iodine Treatment With Cancer Mortality in Patients With Hyperthyroidism.

JAMA internal medicine·2019

Search research articles

Related Experiment Video

Updated: Jul 9, 2026

An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use

An Automated Radiosynthesis of [⁶⁸Ga]Ga-FAPI-46 for Routine Clinical Use

Published on: May 24, 2024

Uncertainty on faecal analysis on dose assessment.

Lígia M Q C Julião¹, Dunstana R Melo, Wanderson de O Sousa

¹Instituto de Radioproteção e Dosimetria, Comissão Nacional de Energia Nuclear, Av. Salvador Allende s/n. Via 9, Recreio, CEP 22780-160, Rio de Janeiro, RJ, Brazil. ligia@ird.gov.br

Radiation Protection Dosimetry

|December 18, 2007

Summary

For accurate internal dose assessment, collecting faecal samples over three consecutive days and analyzing them as a pooled sample is recommended. This method accounts for significant daily variations in excretion, improving the reliability of dose estimations, especially for insoluble compounds.

More Related Videos

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Published on: September 4, 2017

Related Experiment Videos

Last Updated: Jul 9, 2026

An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use

An Automated Radiosynthesis of [⁶⁸Ga]Ga-FAPI-46 for Routine Clinical Use

Published on: May 24, 2024

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Published on: September 4, 2017

Area of Science:

Radiological Protection
Occupational Health
Bioassay Techniques

Background:

Internal dose assessment programs often require multiple bioassay techniques.
Faecal analysis is crucial for insoluble compounds where urinary excretion may be undetectable.
Accidental intakes and handling of compounds with varying solubilities necessitate robust monitoring.

Purpose of the Study:

To investigate the variability of daily faecal excretion for internal dose assessment.
To determine the optimal duration and method for faecal sample collection and analysis.
To provide recommendations for improving the accuracy and efficiency of dose monitoring.

Main Methods:

Comparison of faecal excretion data from one-day collection versus three-day consecutive collection.
Analysis of individual daily samples versus pooled samples from the three-day collection.
Evaluation of uranium excretion variability.

Main Results:

Single-day faecal collection shows significant variability (up to a factor of 40 in 24-hour uranium excretion), making it inappropriate for dose assessment.
Three-day consecutive faecal collection, with samples analyzed as a pool, provides a more reliable and representative measure of excretion.
Pooled analysis of three-day samples is more economical and faster than individual sample analysis.

Conclusions:

A single day of faecal collection is insufficient for accurate internal dose assessment.
Collecting faecal samples over three consecutive days and analyzing them as a pooled sample is the recommended approach.
This method enhances the reliability of dose estimations, particularly for insoluble radioactive compounds, while optimizing resources.