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Exercise and type 1 diabetes mellitus in youth; review and recommendations

Mariana Rachmiel1, Jennifer Buccino, Denis Daneman

  • 1Division of Endocrinology, Hospital for Sick Children, Toronto, Canada.

Pediatric Endocrinology Reviews : PER
|December 18, 2007
PubMed

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Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
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