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Updated: Jul 9, 2026

Whole-body Mass Spectrometry Imaging by Infrared Matrix-assisted Laser Desorption Electrospray Ionization (IR-MALDESI)
Published on: March 24, 2016
Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging
Tuhin K Sinha1, Sheerin Khatib-Shahidi, Thomas E Yankeelov
1Department of Radiology and Radiological Sciences, Vanderbilt University, 1161 21st Avenue South, Nashville, Tennessee 37232, USA. tk.sinha@vanderbilt.edu
Abstract:
We have developed a method for integrating three dimensional-volume reconstructions of spatially resolved matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) ion images of whole mouse heads with high-resolution images from other modalities in an animal-specific manner. This approach enabled us to analyze proteomic profiles from MALDI IMS data with corresponding in vivo data provided by magnetic resonance imaging.
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