Adipose Tissue: A Metabolic Regulator. Potential Implications for the Metabolic Outcome of Subjects Born Small for

Related Experiment Video

Updated: Jul 9, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Arianna Maiorana1, Chiara Del Bianco, Stefano Cianfarani

  • 1Rina Balducci Center of Pediatric Endocrinology, Department of Public Health and Cell Biology, Tor Vergata University, 00133-Rome, Italy.

The Review of Diabetic Studies : RDS
|December 18, 2007
PubMed

Insights

Understanding visceral adipose tissue stem cells is crucial for metabolic health. Research suggests their behavior may explain long-term risks associated with low birth weight and intrauterine growth retardation.

Area of Science:

  • Metabolic regulation and stem cell biology.

Background:

  • Adipose tissue regulates metabolism, energy, and immunity.
  • Abdominal obesity contributes to insulin resistance via visceral adipose tissue (VAT) lipolysis and adipocytokine secretion.
  • Low birth weight is linked to central adiposity and increased risk of metabolic syndrome, type 2 diabetes, and cardiovascular disease.

Purpose of the Study:

  • To investigate the role of intrauterine adipogenesis in metabolic syndrome development.
  • To understand the behavior of visceral adipose tissue-derived stem cells (VATSCS).
  • To explore the clinical implications of VATSCS for intrauterine growth retardation (IUGR).

Main Methods:

  • The study focuses on the behavior of VATSCS.

Main Results:

  • VATSCS behavior is key to understanding metabolic risks in IUGR.
  • Further research into VATSCS could reveal mechanisms linking fetal development to adult metabolic disease.

Conclusions:

  • Studying VATSCS offers insights into metabolic alterations associated with IUGR.
  • This knowledge has potential clinical applications for preventing long-term metabolic dysfunction.

More Related Videos

Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator06:08

Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

Localization, Identification, and Excision of Murine Adipose Depots08:53

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Metabolic States of the Body: The Absorptive State01:25

Metabolic States of the Body: The Absorptive State

During the absorptive state, which lasts approximately four hours after a meal, the body absorbs nutrients from the gastrointestinal tract. The carbohydrates, proteins, and lipids we consume are broken down into monosaccharides, amino acids, and free fatty acids for absorption. While carbohydrates and proteins are absorbed as-is, lipids are absorbed in their broken-down forms and then re-esterified into triglycerides within enterocytes before being packaged into chylomicrons. These absorbed...