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Related Concept Videos

Structural Joints: Fibrous Joints01:03

Structural Joints: Fibrous Joints

Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Fibrous Proteins00:55

Fibrous Proteins

Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
Sutures of the Skull01:22

Sutures of the Skull

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...

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Related Experiment Video

Updated: Jul 9, 2026

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
06:38

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis

Published on: October 12, 2016

[Fibrous dysplasia].

R Rödl1, C Götze

  • 1Klinik und Poliklinik für Allgemeine Orthopädie, Universitätsklinikum Münster, Albert-Schweitzer-Strasse 33, 48129 Münster, Deutschland. roedl@uni-muenster.de

Der Orthopade
|December 18, 2007
PubMed
Summary

Fibrous dysplasia is a benign bone disorder that progresses during childhood. While often manageable with conservative treatments, surgical interventions for deformities require careful consideration of device selection.

Area of Science:

  • Orthopedics
  • Genetics
  • Pediatric Endocrinology

Background:

  • Fibrous dysplasia is a benign, tumor-like bone lesion resulting from early embryogenesis mutations.
  • Skeletal involvement and lesion extent increase during childhood, typically until age 15.
  • Polyostotic forms may correlate with endocrine dysfunction requiring early diagnosis and management.

Purpose of the Study:

  • To review the natural history, clinical manifestations, and management strategies for fibrous dysplasia.
  • To highlight the challenges and considerations in treating skeletal deformities associated with the condition.
  • To provide guidance on appropriate treatment modalities for pain, fractures, and deformities.

Main Methods:

  • Literature review of fibrous dysplasia focusing on clinical progression and treatment outcomes.

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Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

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Last Updated: Jul 9, 2026

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
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  • Analysis of management strategies including conservative care, bisphosphonates, and surgical interventions.
  • Evaluation of fracture healing potential and deformity correction techniques.

    • Main Results:

    • Malignant transformation of fibrous dysplasia is rare (<1%), generally not necessitating lesion resection.
    • Bisphosphonates may alleviate pain but do not alter the disease's natural course.
    • Conservative treatment (casts) is effective for limb fractures; surgical correction, especially for proximal femur deformities, is complex.

    Conclusions:

    • Fibrous dysplasia management should focus on symptom control and addressing complications like fractures and deformities.
    • Early diagnosis and treatment of associated endocrine dysfunction are crucial for polyostotic cases.
    • Surgical stabilization for deformities favors intramedullary devices over plates, particularly in challenging areas like the proximal femur.