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Creutzfeldt-Jakob disease with slow progression. A mimickry of progressive supranuclear palsy
F M Huber1, F Bour, V Sazdovitch
1Department of Neurosciences, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg.
Abstract:
Sporadic Creutzfeldt-Jakob disease (sCJD) does not always present with typical clinical signs, such as myoclonus in association with periodic sharp-wave complexes. We present a 67-year old female patient with initial falls and vertical gaze palsy, suggesting the diagnosis of Progressive Supranuclear Palsy (PSP). EEG and MRI were not contributory. Typical clinical and paraclinical CJD signs were only seen after 17 months. The diagnosis was confirmed by autopsy. - CJD can be a neurodegenerative chameleon. The present case adds to the scare literature of slowly evolving CJD mimicking Parkinsonism related to tauopathies.
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