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Updated: Jul 9, 2026

A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
Potential mechanism for transition between acute hypercapnia during sleep to chronic hypercapnia during wakefulness
Kenneth I Berger1, Robert G Norman, Indu Ayappa
1NYU School of Medicine, Department of Medicine, USA. kenneth.berger@med.nyu.edu
Abstract:
This paper presents a series of experiments, both in patients and computer models, investigating the transition from acute to chronic hypercapnia in OSA. The data demonstrate that acute hypercapnia during periodic breathing occurs due to either reduction in magnitude of inter-event ventilation and/or reduction in inter-event ventilatory duration relative to duration of the preceding event. The transition between acute hypercapnia during sleep and chronic sustained hypercapnia during wakefulness may be determined by an interaction between respiratory control and renal handling of HCO3-.
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