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CKD-MBD: impact on management of kidney disease

Hiroaki Ogata1, Fumihiko Koiwa2, Eriko Kinugasa3

  • 1Department of Internal Medicine, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-Chuo, Tsuzuki, Yokohama, 224-8503, Japan. ogatah@med.showa-u.ac.jp.

Clinical and Experimental Nephrology
|December 19, 2007
PubMed

Insights

Chronic kidney disease (CKD) mineral and bone disorder (CKD-MBD) significantly increases cardiovascular risks in dialysis patients. Novel treatments for CKD-MBD may improve outcomes and slow kidney disease progression.

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiovascular Medicine

Background:

  • Chronic kidney disease (CKD) is linked to bone and mineral metabolism abnormalities, termed CKD mineral and bone disorder (CKD-MBD).
  • CKD-MBD is a major contributor to high cardiovascular disease (CVD) rates and mortality in end-stage kidney disease (ESKD) patients.
  • Effective CKD-MBD management may reduce cardiovascular complications and potentially slow CKD progression.

Purpose of the Study:

  • To review emerging therapeutic strategies for managing CKD-MBD.
  • To highlight novel agents for improving mineral and bone health in CKD patients.

Main Methods:

  • Literature review of recent advancements in CKD-MBD treatment.
  • Focus on novel pharmacological agents and their clinical applications.

Main Results:

  • New treatments for CKD-MBD are now available.
  • These include active vitamin D analogues, phosphate binders free of calcium, and cinacalcet.

Conclusions:

  • Novel therapeutic agents offer new options for managing CKD-MBD.
  • Optimizing CKD-MBD treatment is crucial for reducing cardiovascular morbidity and mortality in ESKD.
  • These strategies may also positively impact CKD progression.

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