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Polysaccharide-based tissue adhesives for sealing corneal incisions
Sujata K Bhatia1, Samuel D Arthur, H Keith Chenault
1Biochemical Sciences and Engineering, Central Research and Development, DuPont Experimental Station, Wilmington, Delaware 19880, USA. sujata.k.bhatia@usa.dupont.com
Current Eye Research
|December 19, 2007
Summary
A novel polysaccharide-based tissue adhesive effectively seals corneal incisions, demonstrating high leak pressure resistance. This ophthalmic surgical adhesive is also non-cytotoxic to corneal endothelial cells, indicating its safety.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Tissue Engineering
Background:
- Corneal incisions in ophthalmic surgery require effective sealing to prevent leakage and promote healing.
- Current methods for corneal wound closure may have limitations, necessitating the development of advanced sealing agents.
Purpose of the Study:
- To evaluate the efficacy of a novel polysaccharide-based tissue adhesive in sealing corneal incisions.
- To assess the cytotoxic effects of this new adhesive on corneal endothelial cells.
Main Methods:
- A polysaccharide-based adhesive (dextran aldehyde and star PEG amines) was applied to 5-mm corneal incisions in enucleated rabbit eyes.
- Leak pressure was measured to determine sealing effectiveness.
- Cytotoxicity was assessed by incubating the adhesive with bovine corneal endothelial cells.
Main Results:
- The polysaccharide-based tissue adhesive successfully sealed corneal incisions up to pressures exceeding 10 psi (500 mmHg).
- The adhesive exhibited no cytotoxic effects on corneal endothelial cells.
Conclusions:
- Polysaccharide-based tissue adhesives are effective for sealing corneal wounds in ophthalmic applications.
- The demonstrated non-cytotoxicity makes this adhesive a promising new technology for ophthalmic surgery.
