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Updated: Jun 8, 2026

Rabies Necropsy Techniques in Large and Small Animals

Rabies Necropsy Techniques in Large and Small Animals

Published on: July 30, 2019

Recovery from rabies in man.

C Porras, J J Barboza, E Fuenzalida

Annals of Internal Medicine

|July 1, 1976

Summary

A nonfatal human rabies case was documented in Argentina following a dog bite. The patient developed severe neurological symptoms but recovered after receiving suckling mouse brain vaccine, showing exceptionally high antibody titers.

Area of Science:

Neurology
Infectious Diseases
Immunology

Background:

Rabies is a fatal viral zoonosis transmitted primarily through dog bites.
Timely post-exposure prophylaxis (PEP) is crucial for preventing rabies.
The efficacy of suckling mouse brain vaccine (SMBV) in severe rabies cases is a critical concern.

Observation:

A 45-year-old woman in Argentina was bitten by a dog exhibiting rabies symptoms.
The patient received 14 doses of SMBV and two boosters, 10 days post-exposure.
She developed severe cerebellar and encephalitic symptoms, persisting for months.

Findings:

The patient exhibited an unprecedented immune response, with rabies-neutralizing antibody titers reaching 1:640,000 in serum and 1:160,000 in cerebrospinal fluid.

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These antibody levels far exceed those typically observed after SMBV treatment.

Despite severe initial symptoms, the patient achieved near-complete recovery after 13 months.

Implications:

This case suggests that nonfatal rabies in humans is possible, even with severe initial symptoms.
The study highlights a potentially robust immune response to SMBV in certain individuals.
Further research is warranted to understand the mechanisms behind such high antibody production and its correlation with recovery in rabies patients.