Transplant recipient renal function is donor renal mass- and recipient gender-dependent

Area of Science:

• Nephrology
• Transplant Surgery
• Immunology

Background:

• Donor renal mass and recipient gender are critical factors in kidney transplant outcomes.
• Previous studies have not fully elucidated the combined effects of donor and recipient sex on graft function.

Purpose of the Study:

• To investigate the influence of donor renal mass and gender on kidney function in recipients of different genders.
• To analyze graft performance across various donor-recipient sex combinations.

Main Methods:

• Analysis of 730 living-donor renal transplants stratified into four donor-recipient groups: female-female, male-female, female-male, and male-male.
• Comparison of groups based on age, race, BMI, match, ischemia time, operative time, and estimated glomerular filtration rate (eGFR).

Main Results:

• Male recipients of male kidneys showed higher eGFR for 3 years.
• Female recipients had lower serum creatinine.
• Male recipients receiving female allografts had higher serum creatinine.
• Male kidneys experienced a 15-20 ml/min eGFR loss in female recipients, possibly linked to androgen deprivation.
• Female kidneys improved eGFR by 7-10 ml/min in male recipients.

Conclusions:

• Donor renal mass and gender significantly affect recipient graft function.
• Recipient renal function correlates with donor renal mass within each group.
• Graft function expectations should consider donor-recipient gender and mass disparities.