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Related Experiment Video

Updated: Jul 9, 2026

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane

Published on: August 22, 2025

Oxybutynin-associated esotropia.

Elaine Y H Wong¹, Anton Harding, Lionel Kowal

¹Ocular-Motility Clinic, The Royal Victorian Eye and Ear Hospital, Melbourne, Australia. e.wong@unimelb.edu.au

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus

|December 19, 2007

Summary

Oxybutynin, used for enuresis, can trigger esotropia in children with hyperopia by reducing accommodation. Correcting hyperopia and stopping oxybutynin resolved the esotropia.

Related Experiment Videos

Last Updated: Jul 9, 2026

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane

Published on: August 22, 2025

Area of Science:

Ophthalmology
Pediatrics
Pharmacology

Background:

Hyperopia is a common refractive error in children.
Enuresis is often treated with anticholinergic medications like oxybutynin.
Anticholinergic drugs can affect accommodation, the eye's ability to focus.

Observation:

A 5-year-old girl with undiagnosed hyperopia developed esotropia during oxybutynin treatment.
The esotropia resolved after discontinuing oxybutynin and correcting her hyperopia.
A small esophoria remained after hyperopic correction removal.

Findings:

Oxybutynin's anticholinergic effect likely reduced accommodative ability.
This reduction in accommodation increased accommodative convergence.
The imbalance between accommodation and convergence triggered esotropia.

Implications:

Anticholinergic medications should be used cautiously in children with uncorrected hyperopia.
Esotropia may be an iatrogenic effect of oxybutynin in susceptible individuals.
Early detection and correction of hyperopia are crucial for preventing vision disorders.