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Related Experiment Video

Updated: Jul 9, 2026

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis

Published on: May 12, 2020

Mycobacterium fortuitum keratitis.

¹Department of Ophthalmology, Royal Eye Hospital, Oxford Road, Manchester, M13 9WH, United Kingdom. casanghvi@yahoo.co.uk

Indian Journal of Medical Microbiology

|December 19, 2007

Summary

This case study details a rare mycobacterial keratitis infection with a sudden onset. Despite aggressive treatment including antibiotics and corneal grafts, the condition led to eye removal.

Area of Science:

Ophthalmology
Infectious Diseases

Background:

Mycobacterial keratitis is a rare but serious eye infection.
Early diagnosis and treatment are crucial for preventing vision loss.

Observation:

A patient presented with a spontaneous onset of mycobacterial keratitis.
Diagnosis was significantly delayed, complicating management.
The infection was resistant to systemic antibiotics and multiple corneal grafts.

Findings:

The case highlights the aggressive nature of certain mycobacterial corneal infections.
Treatment challenges included delayed diagnosis and therapeutic resistance.
Evisceration was ultimately required due to disease progression.

Implications:

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Emphasizes the need for heightened clinical suspicion for mycobacterial keratitis, especially with atypical presentations.
Underscores the limitations of conventional treatments in severe or delayed cases.
Suggests potential need for novel diagnostic and therapeutic strategies for resistant mycobacterial keratitis.