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Updated: Jul 9, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

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DR5 activation of caspase-8 induces DC maturation and immune enhancement in vivo

Michael A Chattergoon1, Karuppiah Muthumani, Yutaka Tamura

  • 1Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Molecular Therapy : the Journal of the American Society of Gene Therapy
|December 19, 2007
PubMed

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The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
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B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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T Cell Types and Functions

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Cytotoxic T Cells-mediated Immune Response

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