Birth weight and melanoma risk: a population-based case-control study

We investigated whether lower birth weight was associated with lower risk of melanoma later in life. This population-based case-control study included all incident cases of histologically verified invasive melanoma diagnosed until 31 December 2003 in the Norwegian population born between 1967 and 1986 (n=709). The control group without malignant disease was established by random sampling from the same source population as the cases (n=108 209). Data on birth weight, gender, mother's residence and parental age at the time of birth were collected from the Medical Birth Registry of Norway and data on cancer from the Cancer Registry of Norway. The Mantel-Haenszel test of linear trend showed no trend in risk across the birth weight categories: individuals in the highest quartile of birth weight (>or=3860 g) had an odds ratio (OR) of 1.19 (95% confidence interval, CI: 0.77-1.84) compared to individuals with birth weight <2500 g. The adjusted OR was 0.81 (95% CI: 0.52-1.26) for birth weight below 2500 g (exposed). Though not statistically significant, the results suggest that low birth weight might influence the risk of melanoma later in life.