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Related Experiment Video

Updated: Jul 9, 2026

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

Ritodrine pharmacokinetics in twin pregnancy patients.

A Konda¹, A Nodai, M Soma

¹Department of Pharmacy, Tenshi Hospital, Sapporo, Japan.

European Journal of Clinical Pharmacology

|December 19, 2007

Summary

Ritodrine serum concentrations increased in twin pregnancies due to decreased clearance in some patients. Further studies are needed to optimize ritodrine therapy for twin pregnancies.

Related Experiment Videos

Last Updated: Jul 9, 2026

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

Area of Science:

Pharmacology
Obstetrics
Maternal-Fetal Medicine

Background:

Ritodrine is used to manage preterm labor.
Understanding ritodrine pharmacokinetics is crucial for effective and safe tocolytic therapy, especially in complex pregnancies like twin gestations.

Purpose of the Study:

To investigate the pharmacokinetic profile of ritodrine in twin pregnancy patients.
To correlate serum ritodrine concentrations with therapeutic outcomes.
To establish a basis for rational ritodrine dosing in twin pregnancies.

Main Methods:

Serum ritodrine concentrations were measured in 14 twin pregnancy patients.
High-performance liquid chromatography (HPLC) was employed for precise quantification.
Pharmacokinetic parameters were analyzed in relation to gestational age and individual patient data.

Main Results:

Patients exhibited linear ritodrine pharmacokinetic profiles.
A slight negative correlation was observed between gestational period and ritodrine clearance.
Three out of 14 patients showed a significant decrease in total body clearance, leading to increased serum ritodrine levels.

Conclusions:

Decreased ritodrine clearance in a subset of twin pregnancy patients contributes to elevated serum concentrations near term.
Individual pharmacokinetic variability necessitates further research for tailored ritodrine therapy.
Additional studies are required to define optimal and safe ritodrine regimens for twin pregnancies.