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[Effect of antibiotics on the resistance of white mice to C1. perfringens toxin]
Antibiotiki
|August 1, 1975
Abstract:
The effect of potassium benzylpenicillin, streptomycin sulfate and chlortetracycline on experimental gangrenous intoxication was studied. When the antibiotics were injected before intoxication, the albino mice resistance did not significantly change. When the antibiotics were injected immediately after the toxin administration, the resistance of the test animals markedly decreased.
Insights
Antibiotic administration timing critically impacts experimental gangrenous intoxication outcomes. Injecting antibiotics like penicillin and streptomycin before toxin exposure showed no protective effect in mice, while post-exposure injection worsened outcomes.
Area of Science:
- Microbiology
- Pharmacology
- Toxicology
Context:
- Investigating the efficacy of common antibiotics against bacterial toxins.
- Assessing the impact of antibiotic administration timing on intoxication.
- Utilizing a murine model for experimental gangrenous intoxication.
Purpose:
- To determine the therapeutic window for penicillin, streptomycin, and chlortetracycline in treating experimental gangrenous intoxication.
- To evaluate the influence of pre- vs. post-intoxication antibiotic administration on animal survival and resistance.
Summary:
- Potassium benzylpenicillin, streptomycin sulfate, and chlortetracycline were tested against experimental gangrenous intoxication in albino mice.
- Pre-intoxication antibiotic administration did not significantly alter mouse resistance to the toxin.
- Immediate post-intoxication antibiotic administration markedly decreased animal resistance, suggesting a detrimental effect.
Impact:
- Highlights the critical importance of administration timing for antibiotic efficacy in intoxication models.
- Suggests potential adverse effects or inefficacy of these antibiotics when given after toxin exposure.
- Informs future research on therapeutic strategies for bacterial intoxication and antibiotic use.