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Related Experiment Videos

Effect on ochratoxin A on Lohmann-type chicks.

I A Ayed1, R Dafalla, A I Yagi

  • 1Department of Veterinary Medicine, Pharmacology and Toxicology, University of Khartoum, Sudan.

Veterinary and Human Toxicology
|December 1, 1991
PubMed
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Ochratoxin A exposure in young chicks significantly impaired growth and feed efficiency. This mycotoxin also caused notable changes in blood parameters and organ damage, indicating toxicity.

Area of Science:

  • Veterinary Toxicology
  • Animal Nutrition
  • Poultry Science

Background:

  • Ochratoxin A (OA) is a common mycotoxin found in feed that can negatively impact animal health.
  • Poultry are particularly susceptible to the toxic effects of mycotoxins.
  • Understanding the specific effects of OA on growing chicks is crucial for feed safety and animal welfare.

Purpose of the Study:

  • To investigate the toxicological effects of dietary Ochratoxin A on Lohmann-type chicks.
  • To evaluate the impact of OA on growth performance, blood parameters, and organ pathology in young poultry.

Main Methods:

  • Lohmann-type chicks were fed a diet containing 0.5 ppm Ochratoxin A from 7 days of age for 4 weeks.
  • Growth performance (body weight, feed utilization) was monitored.

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  • Serum biochemical parameters (SDH, GDH, uric acid, total protein, potassium) and hematological parameters (Hb, PCV, RBC, WBC) were analyzed.
  • Organ pathology and gross lesions were examined.

    • Main Results:

    • Chicks fed Ochratoxin A exhibited significantly reduced body weights and impaired feed utilization.
    • Increased serum activity of sorbitol dehydrogenase (SDH) and glutamate dehydrogenase (GDH), along with elevated uric acid concentrations, were observed.
    • Significant decreases in serum total protein, potassium, hemoglobin (Hb), packed cell volume (PCV), red blood cell (RBC), and white blood cell (WBC) counts were noted.
    • Histopathological examination revealed lesions in vital organs, including hemorrhage in the thigh, with slow kidney recovery after diet withdrawal.

    Conclusions:

    • Dietary Ochratoxin A at 0.5 ppm causes significant growth depression and metabolic disturbances in young Lohmann-type chicks.
    • OA exposure leads to hematological abnormalities and organ damage, highlighting its toxicity.
    • Kidney function impairment was evident, with evidence of slow recovery post-exposure cessation.