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The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
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Recollections on thrombin generation

H Coenraad Hemker1

  • 1Synapse BV, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands. hc.hemker@thrombin.com

Journal of Thrombosis and Haemostasis : JTH
|December 20, 2007
PubMed

Against an autobiographic background, a historical sketch is given of the development of the technique of thrombin generation, from subsampling to duly calibrated continuous measurement with fluorogenic substrates. Its application to various problems in the pathophysiology of hemostasis and thrombosis is discussed.

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