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MMP-2 regulates human platelet activation by interacting with integrin alphaIIbbeta3

W-S Choi1, O-H Jeon, H-H Kim

  • 1National Research Laboratory, Department of Biochemistry, College of Science, Yonsei University, Seoul, Korea. dskim@yonsei.ac.kr

Journal of Thrombosis and Haemostasis : JTH
|December 20, 2007
PubMed
Summary

Matrix metalloproteinase-2 (MMP-2) regulates platelet activation and aggregation by binding to integrin alpha(IIb)beta(3). Blocking this interaction with MMP-2’s hemopexin-like domain inhibits platelet activation markers and aggregation.

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