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Updated: Jul 9, 2026
11:52
Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
Published on: January 27, 2023
[Osteoclasts take part in modulation for bone marrow hematopoietic microenvironment--review]
Heng Zhu1, Xiao-Xia Jiang, Ning Mao
1Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
|December 20, 2007
Summary
Osteoclasts, derived from hematopoietic stem cells, are crucial for bone remodeling and immune cell development within the bone marrow. Emerging research highlights their roles in homeostasis, progenitor mobilization, and osteoimmunology, offering potential therapeutic avenues.
Area of Science:
- Hematology
- Immunology
- Cell Biology
- Skeletal Biology
Context:
- The bone marrow hematopoietic microenvironment supports hematopoiesis and immune cell development.
- Osteoclasts are specialized bone-resorbing cells crucial for bone remodeling.
- Recent studies reveal novel roles for osteoclasts in homeostasis and immune regulation.
Purpose:
- To review the origin, identification, and function of osteoclasts.
- To explore the regulation of hematopoietic stem cell mobilization by osteoclasts.
- To discuss the interplay between osteoclasts and the immune system (osteoimmunology).
Summary:
- Osteoclasts, originating from hematopoietic stem cells, are key players in bone remodeling within the bone marrow.
- This review examines osteoclast biology, their interaction with hematopoietic stem cells, and their role in osteoimmunology.
- Understanding these interactions is vital for addressing bone and immune-related disorders.
Impact:
- Provides a comprehensive overview of osteoclast functions in the bone marrow.
- Highlights the emerging field of osteoimmunology and its clinical relevance.
- Suggests potential therapeutic targets for hematopoietic, bone, and immunologic diseases, including cancer.
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