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[Osteoclasts take part in modulation for bone marrow hematopoietic microenvironment--review]

Heng Zhu1, Xiao-Xia Jiang, Ning Mao

  • 1Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|December 20, 2007
PubMed

Bone marrow hematopoietic microenvironment occupies the medullary cavities of bones throughout the skeleton and provides support for hematopoiesis and immune cells development. Bone-resorbing osteoclasts in bone marrow environment are specialized cells derived from the hematopoietic stem cells and play a pivotal role in process termed as bone remodeling that involves break down and build-up of bone. It is only recently that studies have provided a novel basis for understanding potential role of osteoclasts in homeostasis, stress-induced mobilization of hematopoietic progenitors and osteoimmunology. Further exploration on the interaction of osteoclasts with others in bone marrow hematopoietic microenvironment may contribute to future clinical treatments for hematopoietic and bone-related immunologic disorders including cancer. In this review the origin and identification of osteoclasts and regulation of mobilizing hematopoietic stem cells, as well as osteoclasts and osteoimmunity were mainly concerned.

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