Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Dyspnea--disproportion between expense and success].

U Smidt1

  • 1Forschungsinstitut für Lungenkrankheiten und Tuberkulose, Berlin-Buch.

Zeitschrift Fur Erkrankungen Der Atmungsorgane
|January 1, 1991
PubMed
Summary

Dyspnea, or shortness of breath, arises from a mismatch between the body's effort and its respiratory outcome. This imbalance can occur at multiple physiological levels, explaining various forms of dyspnea.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Comment on E. Stresemann: An evil expert witness, a fallen angel?].

Versicherungsmedizin·2002
Same author

[Fractional CO uptake in breathing at risk for detection of diffusion disorder. Comparative cross-sectional and longitudinal validation with the single breath method].

Pneumologie (Stuttgart, Germany)·2001
Same author

[Comment on X. Baur, C. Sieger: Evaluation of residual working capacity with lung function studies].

Versicherungsmedizin·2000
Same author

[Reflections on the new occupational disease No. 4111: without reasonable doubt Mr. X. in his 70th year suffers from chronic obstructive bronchitis and Mr. Y. from pulmonary emphysema].

Pneumologie (Stuttgart, Germany)·1999
Same author

[Semi-quantitative diagnosis of the degree of emphysema from CO2 expirograms].

Pneumologie (Stuttgart, Germany)·1997
Same author

[Diagnostic value of diffusion in the gas space of the emphysematous lung].

Pneumologie (Stuttgart, Germany)·1995

Area of Science:

  • Physiology
  • Respiratory Medicine
  • Pathophysiology

Context:

  • Dyspnea is a complex symptom with multifactorial origins.
  • Existing theories do not fully encompass all causes of dyspnea.
  • Understanding the physiological basis of dyspnea is crucial for diagnosis and treatment.

Purpose:

  • To propose a unifying theory for the diverse causes of dyspnea.
  • To identify the common underlying mechanism across different forms of dyspnea.
  • To re-evaluate the role of traditional physiological markers in dyspnea.

Summary:

  • A novel theory posits that dyspnea results from a disproportion between physiological 'input' (e.g., neural drive) and 'output' (e.g., ventilatory effect).
  • This input-output imbalance can manifest at various levels: psychological drive vs. neural response, neural excitation vs. muscular response, or muscular activity vs. ventilatory effect.
  • Conditions like cardiac failure leading to insufficient respiratory muscle perfusion exemplify this mechanism.
  • Arterial oxygen pressure is identified as a potentially misleading indicator in cases like anemia or carbon monoxide poisoning, where oxygen transport is compromised without necessarily causing dyspnea.

Impact:

  • This theory offers a new framework for understanding and classifying dyspnea.
  • It may guide the development of more accurate diagnostic tools and targeted therapies for patients experiencing shortness of breath.
  • Revising the interpretation of physiological parameters like arterial oxygen pressure in specific clinical contexts is suggested.

Related Experiment Videos