[Isocapnic cold air provocation in healthy probands]

To study the physiological response to cold air challenge, the "flow-volume-loop" method was used. Fifty-one healthies (31 males and 20 females, mean age 30 +/- 9 years) served as the subjects. Measurements were done before and subsequently 5 and 30 min after challenge. In normal subjects it were observed both an increase and decrease of the airway obstruction. All registered changes were statistically significant. The range of normal alterations of parameters as a response to the cold air challenge was calculated on the base of obtained data.