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[Isocapnic cold air provocation in healthy probands]
P P Gorbenko1, N A Silber, E A Melnikowa
1Medizin-Ingenieurzentrum AEROSOL, Leningrad, UdSSR.
Zeitschrift Fur Erkrankungen Der Atmungsorgane
|January 1, 1991
Summary
Cold air challenges cause significant, variable changes in airway obstruction for healthy individuals. Researchers quantified these normal physiological responses using the flow-volume-loop method.
Area of Science:
- Pulmonary physiology
- Respiratory medicine
Context:
- Assessing physiological responses to environmental challenges is crucial for understanding respiratory health.
- Cold air exposure is a known trigger for respiratory changes.
Purpose:
- To investigate the physiological effects of a cold air challenge on airway obstruction in healthy adults.
- To establish the range of normal alterations in respiratory parameters following cold air exposure.
Summary:
- This study utilized the flow-volume-loop method to measure airway obstruction changes in 51 healthy subjects before and after a cold air challenge.
- Statistically significant increases and decreases in airway obstruction were observed, indicating variable physiological responses.
- The study calculated the range of normal parameter alterations in response to cold air.
Impact:
- Provides a baseline for normal physiological responses to cold air, aiding in the interpretation of respiratory challenges.
- Contributes to understanding the variability of airway obstruction in healthy individuals under environmental stress.