Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adherence to immunosuppression: a prospective diary study.

E J Gordon1, T R Prohaska, M P Gallant

  • 1Department of Medicine, Albany Medical Center, Albany, New York 12208, USA. gordone1@mail.amc.edu

Transplantation Proceedings
|December 20, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A narrative review of family members' experience of organ donation request after brain death in the critical care setting.

Intensive care medicine·2019
Same author

Social media and organ donation: Ethically navigating the next frontier.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

Regional Differences in Communication Process and Outcomes of Requests for Solid Organ Donation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

A Comparison of Request Process and Outcomes in Donation After Cardiac Death and Donation After Brain Death: Results From a National Study.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

Miscommunicating NOTA Can Be Costly to Living Donors.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

APOL1-Associated End-Stage Renal Disease in a Living Kidney Transplant Donor.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same journal

Acute Rejection Mediated by Preformed Anti-HLA-C Antibody in a Kidney Transplant Patient: A Case Report.

Transplantation proceedings·2026
Same journal

Liver Transplantation for Metastatic Neuroendocrine Tumors: A Single-Center Experience in a Brazilian Referral Center.

Transplantation proceedings·2026
Same journal

Analysis of the Cost of Maintaining Effective Donors and Nondonors of Organs and Tissues in Intensive Care Units.

Transplantation proceedings·2026
Same journal

Adolescence and Pediatric Heart Transplantation: Impact of Non-Adherence on Mortality: A Single-Center Experience.

Transplantation proceedings·2026
Same journal

Impact of Family-Based Care on the Outcome of Brain Death and Humanization in the Process of Multiple Organ Donation: Case Report.

Transplantation proceedings·2026
Same journal

Karnofsky Performance Status Is Associated with Patient and Graft Survival After Liver Retransplantation.

Transplantation proceedings·2026
See all related articles

Most kidney transplant recipients struggle with medication adherence, often taking immunosuppressants late. Interventions are needed to improve timely medication intake and support graft survival.

Area of Science:

  • Nephrology
  • Transplantation
  • Pharmacology

Background:

  • Immunosuppression adherence is critical for kidney transplant graft survival.
  • Nonadherence is prevalent and poses a significant risk to graft outcomes.
  • Limited understanding exists regarding various forms of medication nonadherence beyond missed doses.

Purpose of the Study:

  • To investigate the extent and patterns of medication adherence over time in new kidney transplant recipients.
  • To identify the underlying reasons for medication nonadherence in this patient population.

Main Methods:

  • A prospective study involving 39 new kidney transplant recipients.
  • Participants completed a month-long medication-taking diary to record adherence and reasons for nonadherence.

Related Experiment Videos

  • Diary entries included skipped doses, early/late administration, and dosage alterations.

    • Main Results:

    • 51% of patients completed the diary; 55% reported at least one form of nonadherence.
    • The majority of nonadherence involved taking immunosuppression medication late (average 1.5 hours past prescribed time, 3.1 occasions per patient).
    • Common reasons for late intake included healthcare issues, oversleeping, being away from home, work, and forgetfulness.

    Conclusions:

    • Most kidney transplant recipients exhibit nonadherence, primarily by taking immunosuppressants later than prescribed.
    • Further research is needed to assess the clinical impact of delayed immunosuppression on graft function.
    • Interventions should focus on improving timely medication administration, particularly for patients away from home.