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Related Experiment Video

Updated: Jul 9, 2026

Assessing Activity-based Anorexia in Mice
08:26

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Published on: May 14, 2018

Appetite disorders in uremia.

Juan Jesús Carrero1, Abelardo Aguilera, Peter Stenvinkel

  • 1Division of Renal Medicine, CLINTEC, Karolinska Institutet, Stockholm, Sweden. juan.jesus.carrero@ki.se

Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
|December 20, 2007
PubMed
Summary

Chronic kidney disease (CKD) causes anorexia, leading to malnutrition and poor outcomes. Further research into sex hormones may offer new treatments for CKD-related appetite loss.

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Area of Science:

  • Nephrology
  • Endocrinology
  • Gastroenterology

Background:

  • Chronic kidney disease (CKD) frequently causes anorexia, a complex condition worsening with disease progression.
  • This appetite loss can lead to protein-energy wasting, increased morbidity, and mortality in CKD patients.
  • Uremic anorexia originates from renal failure, including toxin retention and metabolic abnormalities not fully corrected by dialysis.

Purpose of the Study:

  • To review current knowledge on the clinical signs of uremic anorexia.
  • To explore the underlying mechanisms contributing to anorexia in CKD patients.
  • To investigate the potential role of sex hormones in managing anorexia in CKD.

Main Methods:

  • Literature review of uremic anorexia.
  • Analysis of clinical signs and underlying mechanisms.
  • Consideration of megestrol acetate interventions and sex-modulated appetite behavior.

Main Results:

  • Uremic anorexia is a multifactorial disorder linked to renal failure and metabolic issues.
  • Existing treatments like dialysis do not fully resolve anorexia.
  • Sex may influence appetite behavior in CKD patients.

Conclusions:

  • Understanding uremic anorexia requires examining both renal and systemic factors.
  • Megestrol acetate and sex hormone modulation are potential therapeutic avenues.
  • Further exploration of sex hormones is warranted for treating CKD-related anorexia.