Related Experiment Video
Updated: Jul 9, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Effectiveness of antihypertensive treatment in patients with chronic kidney disease
Ewa Król1, Piotr Czarniak, Bolesław Rutkowski
1Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdańsk, Poland. ekrol@amg.gda.pl
Insights
Hypertension is common in chronic kidney disease (CKD) patients, with many undertreated. Early CKD detection and effective hypertension management are crucial for slowing disease progression and improving patient outcomes.
Area of Science:
- Nephrology
- Cardiology
- Public Health
Background:
- Hypertension is a primary driver of chronic kidney disease (CKD) progression.
- Early detection of CKD enables therapeutic interventions to slow disease advancement.
Purpose of the Study:
- To assess the prevalence of hypertension and the effectiveness of its treatment within the Program for Early Detection of CKD in Poland (PolNef).
Main Methods:
- The PolNef program screened participants for CKD.
- Hypertension diagnosis was based on current treatment or blood pressure measurements (≥140/90 mmHg).
- Diagnostic tools included estimated glomerular filtration rate (eGFR), albuminuria, and ultrasound.
Main Results:
- CKD was identified in 456 of 2476 participants (18.4%).
- 68% of the CKD population had hypertension; 21% were untreated, and 22% on medication were effectively treated.
- Hypertension was associated with higher rates of overweight/obesity, microalbuminuria, and abnormal kidney ultrasound findings.
Conclusions:
- A significant portion of the CKD population remains hypertensive and undertreated.
- Effective hypertension management in CKD patients is critical.
- Hypertension is linked to poorer kidney function and indicative ultrasound abnormalities.
Objective:
Hypertension is closely associated with chronic kidney disease (CKD) and is one of the main factors of progression of CKD. Early detection of CKD allows introducing a therapy that slows the progression of CKD.
Setting:
A prevalence of hypertension and effectiveness of its treatment were assessed during the accomplishment of the Program for Early Detection of CKD in Poland (PolNef).
Results:
In 456 of a total of 2476 participants of PolNef program (269 females, 187 males), CKD was recognized. Diagnosis of CKD was made according to classification proposed by K/DOQI and KDIGO. Estimated glomerular filtration rate (eGFR) from serum creatinine, albuminuria and ultrasound examination were the main diagnostic tools. Hypertension was defined on the basis of actual antihypertensive treatment or on the basis of medium value (> or = 140 and/or > or = 90) of three separate measurements of blood pressure. Frequency of hypertension and effectiveness of its treatment, frequency of overweight and obesity, microalbuminuria, and abnormalities in ultrasound examination of urinary system were studied.
Conclusion:
Of the CKD population, 68% were hypertensive, 21% remained without antihypertensive medication, and 22% on medication were effectively treated. Kidney insufficiency with eGFR below 60 ml/min/1.73 m2 was recognized in 9% of CKD population. Also, 63% of women and 39% of men without hypertension had normal body mass compared to 19% of people with CKD and hypertension. Microalbuminuria was found in 51% of women and 66% of men with CKD and hypertension. Increased echogenicity of kidney and simple cysts were detected significantly more often in hypertensive patients.
Related Concept Videos
01:28Chronic Kidney Disease III: Interprofessional Care
01:18Chronic Kidney Disease IV: Nursing Management
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
01:22Heart Failure Drugs: Diuretics
01:25Chronic Kidney Disease I: Introduction
01:25Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant